验证数据展示
产品信息
60137-1-Ig targets NUMB in WB, IF, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IF, CoIP |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse, rat |
| 免疫原 | peptide 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG2a |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | numb homolog (Drosophila) |
| 别名 | h-Numb, h Numb, C14orf41, 2G12B7 |
| 计算分子量 | 71 kDa |
| 观测分子量 | 66-72 kDa |
| GenBank蛋白编号 | BC068476 |
| 基因名称 | NUMB |
| Gene ID (NCBI) | 8650 |
| RRID | AB_10598775 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P49757 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
NUMB, also named as S171, plays a role in the determination of cell fates during development. It is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The degradation of NUMB is induced in a proteasome-dependent manner by MDM2. Four transcript variants encoding different isoforms have been found for this gene. The antibody can bind to all these four isoforms P65, P66, P71 and P72, can't recognize the NUMBL.
发表文章
| Species | Application | Title |
|---|---|---|
Sci Rep Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis.
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Neurosci Lett Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors.
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Mol Biol Rep Different roles of Numb-p72 and Numb-p65 on the trafficking of metabotropic glutamate receptor 5. | ||
Stem Cell Res Ther BM-MSCs overexpressing the Numb enhance the therapeutic effect on cholestatic liver fibrosis by inhibiting the ductular reaction | ||
Cell Rep Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas |