验证数据展示
产品信息
17318-1-PBS targets NUDT18 in IF/ICC, IP, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | IF/ICC, IP, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag11292 Product name: Recombinant human NUDT18 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-323 aa of BC016902 Sequence: MASEGLAGALASVLAGQGSSVHSCDSAPAGEPPAPVRLRKNVCYVVLAVFLSEQDEVLLIQEAKRECRGSWYLPAGRMEPGETIVEALQREVKEEAGLHCEPETLLSVEERGPSWVRFVFLARPTGGILKTSKEADAESLQAAWYPRTSLPTPLRAHDILHLVELAAQYRQQARHPLILPQELPCDLVCQRLVATFTSAQTVWVLVGTVGMPHLPVTACGLDPMEQRGGMKMAVLRLLQECLTLHHLVVEIKGLLGLQHLGRDHSDGICLNVLVTVAFRSPGIQDEPPKVRGENFSWWKVMEEDLQSQLLQRLQGSSVVPVNR 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 |
| 别名 | MTH3, Nucleoside diphosphate-linked moiety X motif 18, EC:3.6.1.58, 8-oxo-dGDP phosphatase NUDT18, 7,8-dihydro-8-oxoguanine phosphatase |
| 计算分子量 | 323 aa, 36 kDa |
| 观测分子量 | 36 kDa |
| GenBank蛋白编号 | BC016902 |
| 基因名称 | NUDT18 |
| Gene ID (NCBI) | 79873 |
| RRID | AB_3669267 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q6ZVK8 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
8-oxo-dGDP phosphatase NUDT18, also known as MTH3, belongs to the Nudix hydrolase family that eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of various nucleotide substrates, cofactors, and signaling molecules (PMID: 35732208, 22556419). NUDT18 is specifically active against 8-oxo-dGDP and hardly cleaves 8-oxo-dGTP. NUDT18 is markedly elevated expression in noncancerous cell lines in comparison to cancerous counterpart, and NUDT18 deficient cells have been reported to exhibit a noticeably reduced proliferation rate (PMID: 38944687).
