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验证数据展示

  • WB analysis of K-562 using 83477-7-RR (same clone as 83477-7-PBS)

    WB analysis of K-562 using 83477-7-RR (same clone as 83477-7-PBS)

    K-562 cells were subjected to SDS PAGE followed by western blot with 83477-7-RR (TrkA antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83477-7-PBS in a different storage buffer formulation.

  • WB analysis of SH-SY5Y using 83477-7-RR (same clone as 83477-7-PBS)

    WB analysis of SH-SY5Y using 83477-7-RR (same clone as 83477-7-PBS)

    SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 83477-7-RR (TrkA antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83477-7-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83477-7-RR

    Affinity and Kinetic Characterization of 83477-7-RR

    Biolayer interferometry (BLl) kinetic assays of 83477-7-RR against Human NTRK1 were performed. The affinity constant is below 1 pM.

TrkA Recombinant monoclonal antibody, PBS Only

TrkA Uni-rAb® Recombinant Antibody for WB, ELISA
Cat No. 83477-7-PBS

产品说明书

CloneNo. 240440D12

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, ELISA

别名

NTRK1, Trk A, TRK, p140 TrkA, MTC

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

83477-7-PBS targets TrkA in WB, ELISA applications and shows reactivity with human samples.

经测试应用 WB, ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag32759

Product name: Recombinant human NTRK1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 537-796 aa of NM_001007792

Sequence: DKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 neurotrophic tyrosine kinase, receptor, type 1
别名 NTRK1, Trk A, TRK, p140 TrkA, MTC
计算分子量88 kDa
观测分子量140 kDa
GenBank蛋白编号NM_001007792
基因名称 NTRK1
Gene ID (NCBI) 4914
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDP04629
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

NTRK1(Neurotrophic tyrosine kinase receptor 1) is located on chromosome 1q23.1 and is responsible for a rare genetic disorder, CIPA (congenital insensitivity to pain with anhidrosis) (PMID: 37907480). As a neurotrophin receptor, NTRK1 is abundantly expressed in human neuronal tissues and plays an integral role in the development and function of the human nervous system (PMID: 27843590). NTRK1 also regulates the survival and proliferation of cholinergic neurons (PMID: 20054812).

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