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验证数据展示

  • WB analysis of HeLa using 60117-2-Ig (same clone as 60117-2-PBS)

    WB analysis of HeLa using 60117-2-Ig (same clone as 60117-2-PBS)

    WB result of NR2F6 antibody (60117-2-Ig, 1:1000) with si-Control and si-NR2F6 transfected HeLa cells. This data was developed using the same antibody clone with 60117-2-PBS in a different storage buffer formulation.

  • IHC staining of human ovary tumor using 60117-2-Ig (same clone as 60117-2-PBS)

    IHC staining of human ovary tumor using 60117-2-Ig (same clone as 60117-2-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 60117-2-Ig (NR2F6 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60117-2-PBS in a different storage buffer formulation.

  • WB analysis using 60117-2-Ig (same clone as 60117-2-PBS)

    WB analysis using 60117-2-Ig (same clone as 60117-2-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 60117-2-Ig (NR2F6 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60117-2-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

NR2F6 Monoclonal antibody, PBS Only

NR2F6 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 60117-2-PBS

产品说明书

CloneNo. 2H2B8

宿主/亚型

Mouse / IgG1

种属反应性

human, rat

应用

WB, IHC, Indirect ELISA

别名

2H2B8, EAR 2, EAR2, EAR-2, ERBAL2

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

60117-2-PBS targets NR2F6 in WB, IHC, Indirect ELISA applications and shows reactivity with human, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, rat
免疫原

CatNo: Ag7614

Product name: Recombinant human NR2F6 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-404 aa of BC002669

Sequence: MAMVTGGWGGPGGDTNGVDKAGGYPRAAEDDSASPPGAASDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELIAQLLRAEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPYGSGQ

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 nuclear receptor subfamily 2, group F, member 6
别名 2H2B8, EAR 2, EAR2, EAR-2, ERBAL2
计算分子量 43 kDa
观测分子量 43 kDa
GenBank蛋白编号BC002669
基因名称 NR2F6
Gene ID (NCBI) 2063
RRIDAB_2155653
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP10588
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

NR2F6 belongs to NR2F subfamily members, which have their roles in the regulation of neurogenesis, organogenesis, and cellular differentiation during embryonic development (PMID:15875024). NR2F6 acts as transcription factor by binding to a TGACCT direct-repeat motif and has been established in controlling facets of central nervous system (CNS) (PMID: 12690040). It is a nuclear attenuator that directly interferes with DNA binding of NF-AT and, subsequently, transcriptional activity of the NF-AT-dependent IL-17 expression. Otherwise, NR2F6 negatively interfered with transcriptional cytokine responses and acted as a barrier against autoimmunity (PMID:18701084).

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