验证数据展示
产品信息
14019-1-AP targets NR2C2AP in ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 | NR2C2AP fusion protein Ag5133 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | nuclear receptor 2C2-associated protein |
| 别名 | NR2C2AP, TRA16 |
| 计算分子量 | 16 kDa |
| GenBank蛋白编号 | BC057837 |
| 基因名称 | NR2C2AP |
| Gene ID (NCBI) | 126382 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q86WQ0 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
NR2C2AP, also named as NR2C2, TRA16, PGR, PSBPC1, NR3C1, AR and OXT, belongs to the NR2C2AP family. It may act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes. NR2C2AP is mainly localized in the nucleus of cells as a repressor to suppress TR4-mediated transactivation. It can also block the interaction between TR4 and TR4 ligand-binding domain through interacting with TR4-DNA-binding and ligand-binding domains. It may function as a novel repressor to selectively suppress the TR4-mediated transactivation.