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验证数据展示

  • WB analysis using 27897-1-AP (same clone as 27897-1-PBS)

    WB analysis using 27897-1-AP (same clone as 27897-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27897-1-AP (NLRP7 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27897-1-PBS in a different storage buffer formulation.

  • IHC staining of human spleen using 27897-1-AP (same clone as 27897-1-PBS)

    IHC staining of human spleen using 27897-1-AP (same clone as 27897-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 27897-1-AP (NLRP7 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27897-1-PBS in a different storage buffer formulation.

  • IHC staining of human spleen using 27897-1-AP (same clone as 27897-1-PBS)

    IHC staining of human spleen using 27897-1-AP (same clone as 27897-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 27897-1-AP (NLRP7 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27897-1-PBS in a different storage buffer formulation.

NLRP7 Polyclonal antibody, PBS Only

NLRP7 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 27897-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

27897-1-PBS targets NLRP7 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag27465

Product name: Recombinant human NLRP7 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-171 aa of BC109125

Sequence: MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTP

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 NLR family, pyrin domain containing 7
别名
计算分子量112 kDa, 115 kDa, 118 kDa
观测分子量112 kDa
GenBank蛋白编号BC109125
基因名称 NLRP7
Gene ID (NCBI) 199713
RRIDAB_3086005
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8WX94
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

NLRP7, also called NALP7 or PYPAF3, is a member of the NOD-like receptors (NLR), a family of proteins that plays a crucial role in the innate immune response. NLRP7 has been reported to emerge from NLRP2 gene. Similar to all inflammasomes, NLRP7 contributes to both pro- and an anti-inflammatory processes, depending on whether it functions in an inflammasome-dependent or independent pathway. The function of NLRP7 inflammasome has also been reported to depend on the master regulatory transcription factor protein that controls cellular inflammation, the NF-kB. In addition to its pro- and anti-inflammatory actions, NLRP7 plays a role in restricting intracellular bacterial replication and can also induce inflammasome assembly upon specific stimulation by FSL-1 (diacylated lipoprotein).

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