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验证数据展示

  • WB analysis using 10908-1-AP (same clone as 10908-1-PBS)

    WB analysis using 10908-1-AP (same clone as 10908-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 10908-1-AP (NAT8 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10908-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse kidney using 10908-1-AP (same clone as 10908-1-PBS)

    IHC staining of mouse kidney using 10908-1-AP (same clone as 10908-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 10908-1-AP (NAT8 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10908-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse kidney using 10908-1-AP (same clone as 10908-1-PBS)

    IHC staining of mouse kidney using 10908-1-AP (same clone as 10908-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 10908-1-AP (NAT8 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10908-1-PBS in a different storage buffer formulation.

NAT8 Polyclonal antibody, PBS Only

NAT8 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 10908-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

Acetyltransferase 2, ATase2, Camello-like protein 1, CCNAT, CML1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

10908-1-PBS targets NAT8 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag1353

Product name: Recombinant human NAT8 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-227 aa of BC012626

Sequence: MAPCHIRKYQESDRQWVVGLLSRGMAEHAPATFRQLLKLPRTLILLLGGPLALLLVSGSWLLALVFSISLFPALWFLAKKPWTEYVDMTLCTDMSDITKSYLSERGSCFWVAESEEKVVGMVGALPVDDPTLREKRLQLFHLFVDSEHRRQGIAKALVRTVLQFARDQGYSEVILDTGTIQLSAMALYQSMGFKKTGQSFFCVWARLVALHTVHFIYHLPSSKVGSQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 N-acetyltransferase 8 (GCN5-related, putative)
别名 Acetyltransferase 2, ATase2, Camello-like protein 1, CCNAT, CML1
计算分子量 26 kDa
观测分子量25 kDa
GenBank蛋白编号BC012626
基因名称 NAT8
Gene ID (NCBI) 9027
RRIDAB_2149085
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9UHE5
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

NAT8 (N-acetyltransferase 8), also known as ATase2 or camello-like protein 1, is a microsomal enzyme predominantly expressed in the kidney and liver. It catalyzes the final step in mercapturic acid formation by acetylating cysteine S-conjugates, facilitating the detoxification and excretion of electrophilic xenobiotics. Additionally, NAT8 exhibits protein lysine N-acetyltransferase activity, regulating apoptosis and amyloid-beta secretion through BACE1 acetylation. Genetic variants of NAT8 have been implicated in chronic kidney disease progression and blood pressure regulation. (PMID: 20392701; 18402670)

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