Recombinant Mouse TGF-alpha protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse TGF-alpha protein Glu24-Gln97 (Accession# P48030) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 21802 |
| 蛋白编号 | P48030 |
| 预测分子量 | 33.6 kDa |
| SDS-PAGE | 36-44 kDa , reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Transforming growth factor alpha (TGF-alpha) is one growth factor that has been circumstantially implicated in regulating the autocrine growth of breast cancer cells. Expression of TGF alpha can be modulated by activated cellular protooncogenes such as ras and by estrogens. TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
参考文献:
1.Ciardiello, F et al. Annals of oncology : official journal of the European Society for Medical Oncology vol. 2,3 (1991): 169-82. 2.Reddy, C C et al. Medical & biological engineering & computing vol. 36,4 (1998): 499-507. 3.Kumar, V et al. Cell biology international vol. 19,5 (1995): 373-88.
