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Recombinant Mouse PDGFR beta protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg1533

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Synonyms

Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, CD140b, EC:2.7.10.1

验证数据展示

  • Purity of Recombinant Mouse PDGFR beta was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse PDGFR beta was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Mouse PDGFR beta protein Leu32-Val531 (Accession# P05622-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 18596
蛋白编号 P05622-1
预测分子量 82.4 kDa
SDS-PAGE 85-125 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Platelet-derived growth factor receptor β (PDGFR beta) belongs to the family of receptor tyrosine kinases and is widely known for regulating cellular functions like proliferation, angiogenesis, migration, and invasion (PMID: 33744312). It is particularly involved in the development of the vascular system and early hematopoiesis. PDGFR beta signaling has been implicated in a range of diseases, including certain types of cancers where autocrine activation of PDGF signaling pathways is involved. It also plays a role in pathological mesenchymal responses in vascular disorders such as atherosclerosis, restenosis, pulmonary hypertension, and retinal diseases, as well as in fibrotic diseases, including pulmonary fibrosis, liver cirrhosis, scleroderma, glomerulosclerosis, and cardiac fibrosis (PMID：18483217). PDGFR beta localize to the plasma membrane that is abundantly expressed in stromal and mural cells (PMID: 27260205).

参考文献:

1. Yeeravalli R. et al. (2021). Hematol Oncol Stem Cell Ther. 14(4):275-289.
2. Andrae J. et al. (2008). Genes Dev. 22(10):1276-1312.
3. Zhao Y. et al. (2016). Cytotherapy. 18(7):816-827.