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Recombinant Mouse Mesothelin protein (rFc Tag)(HPLC verified)

种属

Mouse

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg2864

Print datasheet

Synonyms

Megakaryocyte-potentiating factor, Mes, Mesothelin, cleaved form, Mpf, Msln

验证数据展示

  • Purity of Recombinant Mouse Mesothelin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Mesothelin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse Mesothelin was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse Mesothelin was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse Mesothelin protein Asp298-Ser600 (Accession# Q61468) with a rabbit IgG Fc tag at the C-terminus.
基因ID 56047
蛋白编号 Q61468
预测分子量 60.2 kDa
SDS-PAGE 62-80 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Mesothelin (MSLN) is a cell-surface glycoprotein with normal expression restricted to mesothelial cells lining the pleura, peritoneum, and pericardium. MSLN is highly expressed in mesothelioma, lung, pancreas, breast, ovarian, and other cancers as a cell-surface antigen implicated in tumor invasion. MSLN is considered to be involved in several mechanisms of cancer pathogenesis. MSLN is emerging as an attractive target for cancer immunotherapy, considering its low expression on normal mesothelial cells and high expression in a broad spectrum of solid tumors.

参考文献:

1.Morello A. et al. (2016) Cancer Discov. 6(2):133-146. 
2.Klampatsa A. et al. (2021) Expert Opin Biol Ther. 21(4):473-486.
3.Cao B. et al. (2021) Int J Biol Sci. 17(14):3850-3861.