Recombinant Mouse MASP1 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse MASP1 protein Arg300-Lys445 (Accession# P98064-1) with a rabbit IgG Fc tag at the C-terminus |
| 基因ID | 17174 |
| 蛋白编号 | P98064-1 |
| 预测分子量 | 42.2 kDa |
| SDS-PAGE | 45-50 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
MASP1, or MBL associated serine protease 1, encodes a serine protease that functions as a component of the lectin pathway of complement activation, which is essential for innate and adaptive immune responses. The lectin pathway becomes activated through MASP-1 autoactivation, and the activated MASP-1 is essential for the activation of MASP-2 and probably MASP-3 (PMID: 27535802). MASP-1 and thrombin effects are synergistic on clot formation (PMID: 26645987).
参考文献:
1. Dobó J. et al. (2016). Sci Rep. 6:31877. 2. Jenny L. et al. (2015). PLoS One. 10(12):e0144633.
