Recombinant Mouse MAdCAM-1 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse MAdCAM-1 protein Gln22-Ser364 (Accession# NP_038619) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 17123 |
| 蛋白编号 | NP_038619 |
| 预测分子量 | 63.1 kDa |
| SDS-PAGE | 68-90kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Lymphocyte recirculation through different organs is thought to be regulated by adhesion molecules ("homing receptors") recognizing tissue-specific vascular addressins on endothelium. The mucosal vascular addressin, MAdCAM1, is an immunoglobulin superfamily adhesion receptor for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. MAdCAM1 can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes.
参考文献:
1. Hamann, A et al. Journal of immunology (Baltimore, Md. : 1950) vol. 152,7 (1994): 3282-93. 2. Berlin, C et al. Cell vol. 74,1 (1993): 185-95. 3. Fu, Shan et al. Cellular and molecular gastroenterology and hepatology vol. 17,2 (2024): 199-217.
