Recombinant Mouse LTBR/TNFRSF3 protein (C-rFc)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse LTBR protein Gln31-Leu223 (Accession# P50284) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 17000 |
| 蛋白编号 | P50284 |
| 预测分子量 | 47.3 kDa |
| SDS-PAGE | 53-65 kDa , reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Lymphotoxin-beta receptor (LTBR) is also named TNFRSF3 and Tumor necrosis factor receptor type III (TNF-RIII; TNFR-III). LTBR is a receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It can activate the NF-kappa-B signaling pathway upon stimulation with lymphotoxin (LTA1-LTB2). LTBR is constitutively expressed on stromal cells and myeloid lineage cells but not on T or B lymphocytes, which may be a novel immune checkpoint of tumor-associated macrophages.
参考文献:
1.Sudhamsu, Jawahar et al. Proceedings of the National Academy of Sciences of the United States of America vol. 110,49 (2013): 19896-901. 2.Wolf, M J et al. Oncogene vol. 29,36 (2010): 5006-18. 3.Wang, Liang et al. iMeta vol. 3,5 e233. 4 Sep. 2024
