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Recombinant Mouse IGFBP6 protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg10273

Print datasheet

Synonyms

IBP-6, IGF-binding protein 6, IGFBP-6, Insulin-like growth factor-binding protein 6

验证数据展示

  • Purity of Recombinant Mouse IGFBP6 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse IGFBP6 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse IGFBP6 protein Ala26-Gly238 (Accession# P47880) with a rabbit IgG Fc tag at the C-terminus.
基因ID 16012
蛋白编号 P47880
预测分子量 48.3 kDa
SDS-PAGE 48-60 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Insulin-like growth factor-binding protein 6 (IGFBP6) is a secreted protein with a uniquely high affinity for IGF-II, distinguishing it within the IGFBP family. Beyond its canonical role as an IGF-II antagonist, IGFBP6 possesses diverse IGF-independent functions, including the activation of MAPK and PI3K/Akt pathways to influence cell migration, survival, and metabolism. It can translocate to the nucleus to induce apoptosis and its activity is modulated by proteolytic cleavage via MMPs. Pathologically, IGFBP6 is a context-dependent regulator: it acts as a tumor suppressor in breast cancer (favorable prognosis), an anti-inflammatory factor in atherosclerosis, a driver of cardiac and hepatic fibrosis, an orchestrator of immune collapse in sepsis, and a predictor of reduced type 2 diabetes risk. Thus, IGFBP6 is a pleiotropic target with dual diagnostic and therapeutic potential across oncology, inflammation, metabolism, and cardiovascular disease.

参考文献:

1.Schwartz, Martin A. Nature cardiovascular research vol. 4,2 (2025): 122-123. 
2.Wang, Zhecun et al. Journal of cellular physiology vol. 235,12 (2020): 9538-9556. 
3.Jin, Zhengxin et al. Communications biology vol. 8,1 1127. 29 Jul. 2025,
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