Recombinant Mouse IGFBP4 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse IGFBP4 protein Asp22-Glu254 (Accession# P47879) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 16010 |
| 蛋白编号 | P47879 |
| 预测分子量 | 51.3 kDa |
| SDS-PAGE | 55-66 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
IGFBP4 (insulin-like growth factor-binding protein 4) is a secreted glycoprotein that binds IGF-I and IGF-II, modulating their bioavailability and signaling. Structurally, it contains an IGFBP domain and a thyroglobulin type-I domain, and its expression is regulated by promoter methylation via MYBBP1A. IGFBP4 participates in several signaling pathways, including negative regulation of canonical Wnt signaling and positive regulation of IGF receptor signaling, and is involved in MAPK cascade, glucose metabolism, and pancreatic β‑cell proliferation. It is being investigated as a prognostic biomarker in liver, renal, endometrial and gastric cancers, and as a therapeutic target in diabetes and Alzheimer‘s disease
参考文献:
1.Liang, Jieling et al. Renal failure vol. 47,1 (2025): 2440528. 2.Sun, Yujing et al. International journal of oncology vol. 66,1 (2025): 4. 3.Ke, Hongqin et al. Experimental eye research, vol. 270 111107. 4 Jun. 2026,
