Recombinant Mouse Her2/ErbB2 protein (His Tag)
种属
Mouse
纯度
>80 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >80 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse Her2 protein Thr23-Thr653 (Accession# P70424) with a His tag at the C-terminus. |
| 基因ID | 13866 |
| 蛋白编号 | P70424 |
| 预测分子量 | 70.7 kDa |
| SDS-PAGE | 75-100 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
HER2/ErbB2 is a critical receptor tyrosine kinase protein belonging to the epidermal growth factor receptor (EGFR) family, which also includes HER1 (EGFR), HER3, and HER4. Unlike other members of the EGFR family, HER2/ErbB2 does not have a known ligand and is often referred to as an "orphan receptor." However, it can form homodimers or heterodimers with other EGFR family members, such as HER1, HER3, and HER4, significantly enhancing its signaling potential. This receptor is involved in the regulation of multiple downstream signaling pathways, including the PI3K-Akt and MAPK pathways, which promote cell survival, proliferation, and migration.
参考文献:
1. Cheng, Xiaoqing. Genes vol. 15,7 (2024): 903. 2. Fry, Elizabeth A et al. Integrative cancer science and therapeutics vol. 3,5 (2016): 593-603.
