Recombinant Mouse HRG protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse HRG protein Leu19-Lys525 (Accession# Q9ESB3) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 94175 |
| 蛋白编号 | Q9ESB3 |
| 预测分子量 | 82.8 kDa |
| SDS-PAGE | 90-120 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Histidine-Rich Glycoprotein (HRG or HPRG) is a highly abundant and multifunctional single-stranded plasma glycoprotein. Because of its unique molecular structure, it can bind to a variety of ligands (such as metal ions, coagulation factors, immune cell surface receptors, etc.). Genetic mutation of HRG (such as high plasma HRG level or abnormal function) is closely related to familial Thrombophilia. In addition, in patients with septicemia, the plasma HRG level usually drops sharply, which is often used as a biomarker of the severity and prognosis of the disease.
参考文献:
1. Foglia, Beatrice et al. Frontiers in immunology vol. 15 1342404. 26 Feb. 2024. 2. Schmaier, Alvin H. Blood advances vol. 7,18 (2023): 5649-5650. 3. Malik, Rida A et al. Blood advances vol. 7,18 (2023): 5651-5660. 4. Jiang, Wei et al. EMBO molecular medicine vol. 16,9 (2024): 2146-2169.
