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Recombinant Mouse Ereg protein (rFc Tag) (HPLC verified)

种属

Mouse

纯度

>90 %, SDS-PAGE
>90%, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg2863

Print datasheet

Synonyms

Epiregulin, EPR, Proepiregulin

验证数据展示

  • Purity of Recombinant Mouse Ereg was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Ereg was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse Ereg was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse Ereg was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90%, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse Ereg protein Val56-Leu101 (Accession# Q61521) with a rabbit IgG Fc tag at the C-terminus.
基因ID 13874
蛋白编号 Q61521
预测分子量 31.4 kDa
SDS-PAGE 33-36 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Ereg, or epiregulin, a member of the EGF family, binds to the epidermal growth factor receptor (EGFR) and ErbB4, and it stimulates EGFR-related downstream pathways. Previous studies have shown that exposure to various chemical carcinogens induces the EREG expression that is relevant to lung tumorigenesis. The exposure of human bronchial epithelial cells to cigarette smoke extract upregulates EREG, which in turn promotes cell proliferation and protects against cigarette smoke-induced cytotoxicity.

参考文献:

1. Sunaga N. et al. (2024). Cancers (Basel). 16(4):710. 
2. Xu X. et al. (2017). Carcinogenesis. 38(6):604-614.
3. Xiong Y. et al. (2021). JTO Clin Res Rep. 2(7):100181.
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