Recombinant Mouse DPPIV/CD26 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse DPPIV/CD26 protein Ser29-His760 (Accession# P28843) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 13482 |
| 蛋白编号 | P28843 |
| 预测分子量 | 110.8 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD26, also known as DPP4 (dipeptidyl peptidase-4), is a 110 kDa type II cell-surface glycoprotein widely expressed on T cells, activated B cells, activated NK cells and myeloid cells as well as on epithelial cells, fibroblasts, mesothelium, and endothelial cells of a variety of tissues. It has ecto-enzyme activity in its extracellular domain and cleaves amino-terminal dipeptides with either L-proline or L-alanine at the penultimate position. CD26 plays roles in diverse biological processes such as immunoregulation, glucose homeostasis, and tumorigenesis. In addition to the 110 kDa monomeric form, a 290 kDa active dimeric form and a 60 kDa fragment of CD26 have also been reported.
参考文献:
1. Pan, Kelsey et al. Cureus vol. 13,2 (2021) e13495. 2. Klemann, C et al. Clinical and experimental immunology vol. 185,1 (2016): 1-21. 3. Morimoto, C, and S F Schlossman. Immunological reviews vol. 161 (1998): 55-70. 4. Bermpohl, F et al. FEBS letters vol. 428,3 (1998): 152-6. 5. Iwaki-Egawa, S et al. Biological chemistry Hoppe-Seyler vol. 374,10 (1993): 973-5.