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Recombinant Mouse CGA protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg3094

Print datasheet

Synonyms

Anterior pituitary glycoprotein hormones common subunit alpha, Cga, Follicle-stimulating hormone alpha chain, Follitropin alpha chain, FSH-alpha

验证数据展示

  • Purity of Recombinant Mouse Cga was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Cga was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse CGA protein Leu25-Tyr116 (Accession# P01216) with a rabbit IgG Fc tag at the C-terminus.
基因ID 12640
蛋白编号 P01216
预测分子量 36.2 kDa
SDS-PAGE 40-50 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CGA (Chromogranin A), known as Chromogranin A, is an acidic, hydrophilic protein consisting of 439 amino acids with a molecular mass of approximately 48 kDa. It is a member of the neuropeptide family and is widely distributed in the neuroendocrine system. CGA has been an attractive therapeutic target and candidate biomarker for a variety of cardiovascular, neurological, and inflammatory diseases. CgA concentration is used as a diagnostic marker in hypertensive pheochromocytoma patients. (PMID: 36902417) Plasma CGA levels are diagnostic in prostate cancer and are particularly important in the monitoring and diagnosis of prostate-specific antigen-negative or progressive prostate cancer with distant metastases.

参考文献:

1. Bralewska M, et al. Int J Mol Sci. 2023;24(5):4986.                                                 
2. Ploussard G, et al. World J Urol. 2023;41(2):361-369.                                              
3. Laguerre F,et al. IUBMB Life. 2020;72(4):524-532.                                                      
4. Iyer DR, et al. Cell Mol Life Sci. 2023;80(9):271.
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