Recombinant Mouse Cd74 protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2716

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Synonyms



产品信息

纯度 >90 %, SDS-PAGE
内毒素 <1.0 EU/μg protein, LAL method
生物活性
Not tested
来源 HEK293-derived Mouse Cd74 protein Gln56-Leu279 (Accession# P04441-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 16149
蛋白编号 P04441-1
预测分子量 28.0 kDa
SDS-PAGE
组分 Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CD74, also known as the invariant chain or HLA class II histocompatibility antigen gamma chain, is a type II transmembrane protein primarily expressed on antigen-presenting cells (APCs). It functions intracellularly as a chaperone for MHC class II molecules, facilitating their assembly and transport to the cell surface. CD74 also serves as a cell surface receptor for macrophage migration inhibitory factor (MIF), playing a role in cell survival and proliferation. Additionally, CD74 has been implicated in various diseases, including cancers and immune-related conditions, making it a potential therapeutic target.

参考文献:

1. Bucala, Richard, and Idit Shachar. Mini reviews in medicinal chemistry vol. 14,14 (2014): 1132-8. 2. Li, Qiu-Lin et al. Frontiers in cardiovascular medicine vol. 9 (2023): 1049143. 3. Vargas, Jasmine, and Georgios Pantouris. International journal of molecular sciences vol. 24,21 (2023): 15981. 4. David, Keren et al. Cell reports vol. 41,5 (2022): 111572.