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Recombinant Mouse Calreticulin protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg3005

Print datasheet

Synonyms

Calr, Calregulin, Calreticulin, CRP55, Endoplasmic reticulum resident protein 60

验证数据展示

  • Purity of Recombinant Mouse Calreticulin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Calreticulin was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Mouse Calreticulin protein Asp18-Leu416(Accession# P14211) with a rabbit IgG Fc tag at the C-terminus.
基因ID 12317
蛋白编号 P14211
预测分子量 72.4 kDa
SDS-PAGE 70-90 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Calreticulin (CRT) is a multifunctional protein with diverse roles in cellular physiology and pathology. It is primarily localized to the endoplasmic reticulum (ER), where it plays a crucial role in protein folding, calcium homeostasis, and the unfolded protein response. CRT also has functions outside the ER, including cell surface expression and extracellular matrix interactions, which are implicated in adhesion, migration, phagocytosis, and immunoregulation. CRT's dysfunction has been linked to various diseases, particularly cancer. It is considered a potential diagnostic marker and therapeutic target for cancer due to its role in cellular proliferation, differentiation, and apoptosis.

参考文献:

1.Nauseef WM. et al. (1995). J Biol Chem. 270(9):4741-4747. 
2.Sun J. et al. (2017). Pharmazie. 72(9):503-510.
3.Gold LI. et al. (2010). FASEB J. 24(3):665-683.