Recombinant Mouse CD320 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse CD320 protein Ala29-Gly208 (Accession# Q9Z1P5-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 54219 |
| 蛋白编号 | Q9Z1P5-1 |
| 预测分子量 | 45.1 kDa |
| SDS-PAGE | 58-70 kDa , reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD320 is a type I transmembrane glycoprotein of LDL receptor family functioning as transcobalamin-bound vitamin B12 receptor. It mediates ligand endocytosis to supply cellular cobalamin essential for DNA synthesis and B lymphocyte proliferation in germinal center. Aberrant CD320 mutation causes inherited methylmalonic aciduria, while its overexpression in liver cancer and multiple myeloma fuels malignant proliferation via enhanced B12 intake. Targeted drug conjugates coupled with cobalamin and anti-CD320 antibodies are under preclinical development for tumor-specific chemotherapy, making CD320 a promising delivery and therapeutic target.
参考文献:
1. Quadros, Edward V et al. Blood vol. 113,1 (2009): 186-92. 2. Alam, Amer et al. Nature communications vol. 7 12100. 14 Jul. 2016.
