Recombinant Mouse CD31/PECAM-1 protein (His Tag)
种属
Mouse
纯度
>85 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >85 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse CD31 protein Glu18-Lys590 (Accession# Q08481-1) with a His tag at the C-terminus. |
| 基因ID | 18613 |
| 蛋白编号 | Q08481-1 |
| 预测分子量 | 65.6 kDa |
| SDS-PAGE | 85-100 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a member of the immunoglobulin gene superfamily of cell adhesion molecules. It is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. CD31 is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell. As well as its role in cell-cell adhesion, CD31 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis.
参考文献:
1. Van Mourik JA. et al. (1985) J Biol Chem. 260:11300–11306. 2. Stockinger H. et al. (1990) J Immunol. 145:3889–3897. 3. Newman PJ. et al. (1990) Science. 247:1219–1222. 4. Newman PJ. (1999) J Clin Invest. 103:5–9. 5. Newton JP. et al. (1997) J Biol Chem. 272:20555–20563.
