Recombinant Mouse CD19 protein (His Tag)
种属
Mouse
纯度
>80 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >80 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse CD19 protein Arg19-Gly287 (Accession# P25918) with a His tag at the C-terminus. |
| 基因ID | 12478 |
| 蛋白编号 | P25918 |
| 预测分子量 | 31.2 kDa |
| SDS-PAGE | 42-55 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD19 is a 95 kDa type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed by B cells and follicular dendritic cells. CD19 is up-regulated at the step of B-lineage commitment during the differentiation of the hematopoietic stem cell, it remains on during subsequent stages of differentiation until finally down-regulated during terminal differentiation into plasma cells. CD19 is involved in B cell development, activation and differentiation. It is the dominant component for the signaling complex on B cells that includes CD21 (CR2), CD81 (TAPA-1) and CD225 and acts as a critical co-receptor for BCR signal transduction.
参考文献:
1.Tedder TF. et al. (1989) J Immunol. 143(2):712-7. 2.Scheuermann RH. et al. (1995) Leuk Lymphoma. 18(5-6):385-97. 3.Wang K. et al. (2012) Exp Hematol Oncol. 1(1):36.
