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Recombinant Mouse ARMETL1 protein (rFc Tag) (HPLC verified)

种属

Mouse

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg2845

Print datasheet

Synonyms

ARMET-like protein 1, Cdnf, Cerebral dopamine neurotrophic factor, Conserved dopamine neurotrophic factor

验证数据展示

  • Purity of Recombinant Mouse ARMETL1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse ARMETL1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse ARMETL1 was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse ARMETL1 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse ARMETL1 protein Leu27-Leu187 (Accession# Q8CC36) with a rabbit IgG Fc tag at the C-terminus.
基因ID 227526
蛋白编号 Q8CC36
预测分子量 44.4 kDa
SDS-PAGE 40-48 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

ARMETL1, also known as Cerebral Dopamine Neurotrophic Factor (CDNF), is a secreted protein with eight conserved cysteine residues. It is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons, comparable to that of glial cell line-derived neurotrophic factor (GDNF). ARMETL1 is known for its neuroprotective and reparative effects, particularly in models of Parkinson's disease and stroke, and is currently in clinical trials for Parkinson's disease.

参考文献:

1.Albert K, et al. (2019). Croat Med J. 60(2):99-108.
2.Lindholm P, et al. (2007). Nature. 448(7149):73-77. 
3.Lohoff FW, et al. (2009). Neurosci Lett. 453(3):199-203.