Recombinant Mouse APRIL/TNFSF13 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse APRIL protein Ala96-Leu241 (Accession# Q9D777) with a rabbit IgG Fc tag at the N-terminus. |
| 基因ID | 69583 |
| 蛋白编号 | Q9D777 |
| 预测分子量 | 43.5 kDa |
| SDS-PAGE | 45-55 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
TNFSF13 (also known as APRIL) is a proliferation-inducing ligand of the tumor necrosis factor (TNF) superfamily. TNFSF13 was found to be involved in immunosuppression via diverse immunoregulation pathways and was associated with other immune checkpoints and inflammation. an abundant expression of TNFSF13 in neoplastic cells and M2 macrophages, which TNFSF13 might potentially regulate the cell communication via IL-8, C3, and CD44. TNFSF13 was proved to interact with two receptors: B cell maturation antigen (BCMA), which germanely combined with TNFSF13 to induce tumor cell invasion and immunosuppression.
参考文献:
1.Chen R, et al. (2021) Front Immunol. 12:713757. 2.Carpenter RO, et al. (2013) Clin Cancer Res. 19(8):2048-60. 3.Tai YT, et al. (2016) Blood. 127(25):3225-36.
