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验证数据展示

  • WB analysis using 25472-1-AP (same clone as 25472-1-PBS)

    WB analysis using 25472-1-AP (same clone as 25472-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 25472-1-AP (MXRA5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 25472-1-AP (same clone as 25472-1-PBS)

    IHC staining of human colon cancer using 25472-1-AP (same clone as 25472-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 25472-1-AP (MXRA5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 25472-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

MXRA5 Polyclonal antibody, PBS Only

MXRA5 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 25472-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

Adlican

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

25472-1-PBS targets MXRA5 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 matrix-remodelling associated 5
别名 Adlican
计算分子量 312 kDa
观测分子量163 kDa, 312 kDa
GenBank蛋白编号NM_015419
基因名称 MXRA5
Gene ID (NCBI) 25878
RRIDAB_2918088
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9NR99
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MXRA5, or adlican, is an adhesion proteoglycan involved in extracellular matrix (ECM) remodeling and cell-cell adhesion (PMID: 22696596). In kidney, MXRA5 has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli (PMID: 27599751). MXRA5 was identified as a novel biomarker in colorectal cancer, mainly located in the cytoplasm of CRC cells (PMID:23420087). Exome sequencing identified MXRA5 as a novel cancer gene mutated in non-small cell lung carcinoma (PMID: 22696596). MXRA5 was detected 163 kDa in human proximal tubular cells (PMID:27599751).

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