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验证数据展示

  • WB analysis using 17034-1-AP (same clone as 17034-1-PBS)

    WB analysis using 17034-1-AP (same clone as 17034-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 17034-1-AP (Methylmalonyl Coenzyme A mutase/MUT antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17034-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 17034-1-AP (same clone as 17034-1-PBS)

    IHC staining of human liver cancer using 17034-1-AP (same clone as 17034-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 17034-1-AP (Methylmalonyl Coenzyme A mutase/MUT antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17034-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with MUT antibody included
  • IHC staining of human liver cancer using 17034-1-AP (same clone as 17034-1-PBS)

    IHC staining of human liver cancer using 17034-1-AP (same clone as 17034-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 17034-1-AP (Methylmalonyl Coenzyme A mutase/MUT antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17034-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with MUT antibody included
  • IP experiment of HepG2 using 17034-1-AP (same clone as 17034-1-PBS)

    IP experiment of HepG2 using 17034-1-AP (same clone as 17034-1-PBS)

    IP result of anti-Methylmalonyl Coenzyme A mutase/MUT (IP:17034-1-AP, 4ug; Detection:17034-1-AP 1:500) with HepG2 cells lysate 1800ug. This data was developed using the same antibody clone with 17034-1-PBS in a different storage buffer formulation.

Methylmalonyl Coenzyme A mutase/MUT Polyclonal antibody, PBS Only

Methylmalonyl Coenzyme A mutase/MUT Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 17034-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IP, Indirect ELISA

别名

MUT, EC:5.4.99.2, MCM, Methylmalonyl CoA isomerase, Methylmalonyl Coenzyme A mutase

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy MUT Ready-To-Use IHC Kit. MUT primary antibody included.

产品信息

17034-1-PBS targets Methylmalonyl Coenzyme A mutase/MUT in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag10523

Product name: Recombinant human MUT protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 401-750 aa of BC016282

Sequence: SARIARNTQIIIQEESGIPKVADPWGGSYMMECLTNDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDTVEVLAIDNTSVRNRQIEKLKKIKSSRDQALAERCLAALTECAASGDGNILALAVDASRARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGESKEITSAIKRVHKFMEREGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVGVSTLAAGHKTLVPELIKELNSLGRPDILVMCGGVIPPQDYEFLFEVGVSNVFGPGTRIPKAAVQVLDDIEKCLEKKQQSV

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 methylmalonyl Coenzyme A mutase
别名 MUT, EC:5.4.99.2, MCM, Methylmalonyl CoA isomerase, Methylmalonyl Coenzyme A mutase
计算分子量 750 aa, 83 kDa
观测分子量 78 kDa
GenBank蛋白编号BC016282
基因名称 MUT
Gene ID (NCBI) 4594
RRIDAB_2147263
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP22033
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Methylmalonyl Coenzyme A mutase (MUT) is an enzyme that plays a crucial role in the metabolism of certain amino acids and fatty acids (PMID: 15647267). Mutations in the MUT gene can lead to methylmalonic acidemia, a metabolic disorder characterized by the accumulation of toxic compounds such as methylmalonyl-CoA and propionyl-CoA (PMID: 30428564), resulting in life-threatening metabolic acidosis, respiratory distress, neurological impairment, hyperammonemia, and ketosis (PMID: 32679819). MUT is essential for maintaining normal metabolic processes and its dysfunction can have significant health implications, highlighting its importance in both basic metabolism and clinical medicine (PMID: 23041189).

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