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验证数据展示

  • WB analysis using 67443-1-Ig (same clone as 67443-1-PBS)

    WB analysis using 67443-1-Ig (same clone as 67443-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67443-1-Ig (MTH1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67443-1-PBS in a different storage buffer formulation.

  • IHC staining of human renal cell carcinoma using 67443-1-Ig (same clone as 67443-1-PBS)

    IHC staining of human renal cell carcinoma using 67443-1-Ig (same clone as 67443-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human renal cell carcinoma tissue slide using 67443-1-Ig (MTH1 antibody) at dilution of 1:4000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67443-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with NUDT1/MTH1 antibody included
  • IHC staining of human colon cancer using 67443-1-Ig (same clone as 67443-1-PBS)

    IHC staining of human colon cancer using 67443-1-Ig (same clone as 67443-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 67443-1-Ig (MTH1 antibody) at dilution of 1:4000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67443-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with NUDT1/MTH1 antibody included
  • IHC staining of human lung cancer using 67443-1-Ig (same clone as 67443-1-PBS)

    IHC staining of human lung cancer using 67443-1-Ig (same clone as 67443-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 67443-1-Ig (MTH1 antibody) at dilution of 1:4000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67443-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with NUDT1/MTH1 antibody included
  • Cytometric bead array standard curve of MP50783-2

    Cytometric bead array standard curve of MP50783-2

    Cytometric bead array standard curve of MP50783-2, NUDT1 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 67443-1-PBS. Detection antibody: 67443-4-PBS. Standard:Ag9802. Range: 0.195-100 ng/mL.

MTH1 Monoclonal antibody, PBS Only (Capture)

MTH1 Monoclonal Antibody for WB, IHC, Cytometric bead array, Indirect ELISA
Cat No. 67443-1-PBS

产品说明书

CloneNo. 2D7G4

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse

应用

WB, IHC, Cytometric bead array, Indirect ELISA

别名

NUDT1, 2D7G4, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, 8 oxo dGTPase

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy NUDT1/MTH1 Ready-To-Use IHC Kit. NUDT1/MTH1 primary antibody included.

产品信息

67443-1-PBS targets MTH1 as part of a matched antibody pair:

MP50783-2: 67443-1-PBS capture and 67443-4-PBS detection (validated in Cytometric bead array)

Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

经测试应用 WB, IHC, Cytometric bead array, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag9802

Product name: Recombinant human NUDT1 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-179 aa of BC014618

Sequence: MSGISPQQMGEPEGSWSGKNPGTMGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 nudix (nucleoside diphosphate linked moiety X)-type motif 1
别名 NUDT1, 2D7G4, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, 8 oxo dGTPase
计算分子量179aa,20 kDa; 197aa,23 kDa
观测分子量 19 kDa
GenBank蛋白编号BC014618
基因名称 MTH1
Gene ID (NCBI) 4521
RRIDAB_2882678
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP36639
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MTH1, also known as NUDT1 or 8-Oxo-dGTPase, is an important repair enzyme that prevents oxidative stress-induced DNA damage through hydrolyzing mutagenic 8-oxo-dGTP into 8-oxo-dGMP. MTH1 is expressed in postmitotic neurons as well as in proliferative tissues, and it is localized both in the mitochondria and nucleus. MTH1 might be a useful marker of oxidative stress and its level increased upon oxidative stress. Increased expression of MTH1 were also found in various cancer tissues and neurodegenerative diseases.

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