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验证数据展示

  • WB analysis using 67443-1-Ig (same clone as 67443-1-PBS)

    WB analysis using 67443-1-Ig (same clone as 67443-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67443-1-Ig (MTH1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67443-1-PBS in a different storage buffer formulation.

  • IHC staining of human renal cell carcinoma using 67443-1-Ig (same clone as 67443-1-PBS)

    IHC staining of human renal cell carcinoma using 67443-1-Ig (same clone as 67443-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human renal cell carcinoma tissue slide using 67443-1-Ig (MTH1 antibody) at dilution of 1:4000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67443-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with NUDT1/MTH1 antibody included
  • IHC staining of human colon cancer using 67443-1-Ig (same clone as 67443-1-PBS)

    IHC staining of human colon cancer using 67443-1-Ig (same clone as 67443-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 67443-1-Ig (MTH1 antibody) at dilution of 1:4000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67443-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with NUDT1/MTH1 antibody included
  • IHC staining of human lung cancer using 67443-1-Ig (same clone as 67443-1-PBS)

    IHC staining of human lung cancer using 67443-1-Ig (same clone as 67443-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 67443-1-Ig (MTH1 antibody) at dilution of 1:4000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67443-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with NUDT1/MTH1 antibody included
  • IF Staining of HeLa using 67443-1-Ig (same clone as 67443-1-PBS)

    IF Staining of HeLa using 67443-1-Ig (same clone as 67443-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using MTH1 antibody (67443-1-Ig, Clone: 2D7G4 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1), CL594-Phalloidin (red). This data was developed using the same antibody clone with 67443-1-PBS in a different storage buffer formulation.

  • Cytometric bead array standard curve of MP50783-2

    Cytometric bead array standard curve of MP50783-2

    Cytometric bead array standard curve of MP50783-2, NUDT1 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 67443-1-PBS. Detection antibody: 67443-4-PBS. Standard:Ag9802. Range: 0.195-100 ng/mL.

MTH1 Monoclonal antibody, PBS Only (Capture)

MTH1 Monoclonal Antibody for WB, IHC, IF/ICC, Cytometric bead array, Indirect ELISA
Cat No. 67443-1-PBS

产品说明书

CloneNo. 2D7G4

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse

应用

WB, IHC, IF/ICC, Cytometric bead array, Indirect ELISA

别名

NUDT1, 2D7G4, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, 8 oxo dGTPase

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy NUDT1/MTH1 Ready-To-Use IHC Kit. NUDT1/MTH1 primary antibody included.

产品信息

67443-1-PBS targets MTH1 as part of a matched antibody pair:

MP50783-2: 67443-1-PBS capture and 67443-4-PBS detection (validated in Cytometric bead array)

Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

经测试应用 WB, IHC, IF/ICC, Cytometric bead array, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag9802

Product name: Recombinant human NUDT1 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-179 aa of BC014618

Sequence: MSGISPQQMGEPEGSWSGKNPGTMGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 nudix (nucleoside diphosphate linked moiety X)-type motif 1
别名 NUDT1, 2D7G4, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, 8 oxo dGTPase
计算分子量179aa,20 kDa; 197aa,23 kDa
观测分子量 19 kDa
GenBank蛋白编号BC014618
基因名称 MTH1
Gene ID (NCBI) 4521
RRIDAB_2882678
偶联类型 Unconjugated
形式Liquid
纯化方式Protein G purification
UNIPROT IDP36639
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MTH1, also known as NUDT1 or 8-Oxo-dGTPase, is an important repair enzyme that prevents oxidative stress-induced DNA damage through hydrolyzing mutagenic 8-oxo-dGTP into 8-oxo-dGMP. MTH1 is expressed in postmitotic neurons as well as in proliferative tissues, and it is localized both in the mitochondria and nucleus. MTH1 might be a useful marker of oxidative stress and its level increased upon oxidative stress. Increased expression of MTH1 were also found in various cancer tissues and neurodegenerative diseases.

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