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验证数据展示

  • WB analysis using 21410-1-AP

    WB analysis using 21410-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 21410-1-AP (MRC2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours.

MRC2 Polyclonal antibody

MRC2 Polyclonal Antibody for WB, ELISA
Cat No. 21410-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, ELISA

别名

ENDO180, C-type mannose receptor 2, C-type lectin domain family 13 member E, CLEC13E, CD280

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

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经过测试的应用

Positive WB detected inHeLa cells, Saos-2 cells, SH-SY5Y cells

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:1000-1:8000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

21410-1-AP targets MRC2 in WB, ELISA applications and shows reactivity with human samples.

经测试应用 WB, ELISA Application Description
经测试反应性 human
免疫原 MRC2 fusion protein Ag15570 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 mannose receptor, C type 2
别名 ENDO180, C-type mannose receptor 2, C-type lectin domain family 13 member E, CLEC13E, CD280
计算分子量 1479 aa, 167 kDa
观测分子量170 kDa
GenBank蛋白编号BC146647
基因名称 MRC2
Gene ID (NCBI) 9902
RRIDAB_3669367
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9UBG0
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

C-type mannose receptor 2 (MRC2), also known as CD280, CLEC13E, ENDO180, KIAA0709, or UPARAP, is a type I transmembrane glycoprotein that belongs to the macrophage mannose receptor protein family (PMID: 10683150; 10636902; 9734811). It contains an N-terminal cysteine-rich domain, a fibronectin type II domain (FNII), eight C-type-lectin-like domains, and a transmembrane region followed by a small cytoplasmic domain (PMID: 34012764). MRC2 is a recycling endocytic receptor that functions in both these cellular activities by promoting cell migration and uptake of collagens for intracellular degradation (PMID: 17974964). MRC2 is expressed in several cells and organs including fibroblasts, endothelial cells, and macrophages. Altered MRC2 expression has been associated with the development and progression of different cancers, including head and neck squamous cell carcinoma, breast cancer, hepatocellular cancer, and prostate cancer (PMID: 36188226; 37666484; 17974964; 25162823).

实验方案

Product Specific Protocols
WB protocol for MRC2 antibody 21410-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols