验证数据展示
产品信息
68530-1-PBS targets MORC2 in WB, Indirect ELISA applications and shows reactivity with Human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | Human |
| 免疫原 |
CatNo: Ag19605 Product name: Recombinant human MORC2 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 617-970 aa of BC136782 Sequence: NTLVKTASRPAPLVQQLSPSLLPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPSRKRSVAVSDEEEVEEEAERRKERCKRGRFVVKEEKKDSNELSDSAGEEDSADLKRAQKDKGLHVEVRVNREWYTGRVTAVEVGKHVVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDELISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKGD 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | MORC family CW-type zinc finger 2 |
| 别名 | KIAA0852, MORC2, ZCW3, ZCWCC1 |
| 计算分子量 | 970 aa, 111 kDa |
| 观测分子量 | 118 kDa |
| GenBank蛋白编号 | BC136782 |
| 基因名称 | MORC2 |
| Gene ID (NCBI) | 22880 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | Q9Y6X9 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
MORC2 is essential for epigenetic silencing by the HUSH (human silencing hub) complex. It can be recruited by HUSH to target site in heterochromatin. MORC2 also recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes.
