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验证数据展示

  • WB analysis of mouse spleen using 17354-1-AP (same clone as 17354-1-PBS)

    WB analysis of mouse spleen using 17354-1-AP (same clone as 17354-1-PBS)

    mouse spleen tissue were subjected to SDS PAGE followed by western blot with 17354-1-AP (MKNK2 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17354-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 17354-1-AP (same clone as 17354-1-PBS)

    IHC staining of human breast cancer using 17354-1-AP (same clone as 17354-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 17354-1-AP (MKNK2 Antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17354-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with MKNK2 antibody included
  • IHC staining of human breast cancer using 17354-1-AP (same clone as 17354-1-PBS)

    IHC staining of human breast cancer using 17354-1-AP (same clone as 17354-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 17354-1-AP (MKNK2 Antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17354-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with MKNK2 antibody included
  • IF Staining of MCF-7 using 17354-1-AP (same clone as 17354-1-PBS)

    IF Staining of MCF-7 using 17354-1-AP (same clone as 17354-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed MCF-7 cells using MKNK2 antibody (17354-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 17354-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

MKNK2 Polyclonal antibody, PBS Only

MKNK2 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 17354-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

MNK2, MAPK signal-integrating kinase 2, MAP kinase-interacting serine/threonine-protein kinase 2, MAP kinase signal-integrating kinase 2, GPRK7

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy MKNK2 Ready-To-Use IHC Kit. MKNK2 primary antibody included.

产品信息

17354-1-PBS targets MKNK2 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag10546

Product name: Recombinant human MKNK2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-158 aa of BC018345

Sequence: MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRWDSHFLLPPHPCRIHVRPGGLVRTVTVNE

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 MAP kinase interacting serine/threonine kinase 2
别名 MNK2, MAPK signal-integrating kinase 2, MAP kinase-interacting serine/threonine-protein kinase 2, MAP kinase signal-integrating kinase 2, GPRK7
计算分子量 465 aa, 52 kDa
观测分子量 47-52 kDa
GenBank蛋白编号BC018345
基因名称 MKNK2
Gene ID (NCBI) 2872
RRIDAB_2878395
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9HBH9
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MKNK2(MAP kinase-interacting serine/threonine-protein kinase 2) is also named as GPRK7, MNK2 and belongs to the CAMK Ser/Thr protein kinase family. It has a conserved C-terminal Erk-interacting domain, a catalytic domain with homology to the calcium/calmodulin-dependent family of kinases, and putative MAP kinase phosphorylation sites located within the T loop of the kinase domain(PMID:9155017). The breast cancer cells express either an uncharacterized form of MNK2 or a cross-reacting MNK2-like protein with the band of 72-75 kDa by western blot(PMID:17130135). MKNK2 has 2 isoforms with the molecular mass of 52 kDa and 47 kDa.

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