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验证数据展示

  • IP experiment of HCT 116 using 26478-1-AP (same clone as 26478-1-PBS)

    IP experiment of HCT 116 using 26478-1-AP (same clone as 26478-1-PBS)

    IP result of anti-C10orf97 (IP:26478-1-AP, 4ug; Detection:26478-1-AP 1:1000) with HCT 116 cells lysate 1920 ug. This data was developed using the same antibody clone with 26478-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse kidney using 26478-1-AP (same clone as 26478-1-PBS)

    IHC staining of mouse kidney using 26478-1-AP (same clone as 26478-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 26478-1-AP (C10orf97 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26478-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse kidney using 26478-1-AP (same clone as 26478-1-PBS)

    IHC staining of mouse kidney using 26478-1-AP (same clone as 26478-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 26478-1-AP (C10orf97 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26478-1-PBS in a different storage buffer formulation.

  • IHC staining of rat heart using 26478-1-AP (same clone as 26478-1-PBS)

    IHC staining of rat heart using 26478-1-AP (same clone as 26478-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat heart tissue slide using 26478-1-AP (C10orf97 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26478-1-PBS in a different storage buffer formulation.

  • IF Staining of U2OS using 26478-1-AP (same clone as 26478-1-PBS)

    IF Staining of U2OS using 26478-1-AP (same clone as 26478-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U2OS cells using MINDY3 antibody (26478-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 26478-1-PBS in a different storage buffer formulation.

MINDY3 Polyclonal antibody, PBS Only

MINDY3 Polyclonal Antibody for IHC, IF/ICC, IP, ELISA
Cat No. 26478-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

IHC, IF/ICC, IP, ELISA

别名

C10orf97, CARP, Dermal papilla-derived protein 5, DERP5, Deubiquitinating enzyme MINDY-3

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

26478-1-PBS targets MINDY3 in IHC, IF/ICC, IP, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 IHC, IF/ICC, IP, ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag23520

Product name: Recombinant human C10orf97 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-136 aa of BC067799

Sequence: MSELTKELMELVWGTKSSPGLSDTIFCRWTQGFVFSESEGSALEQFEGGPCAVIAPVQAFLLKKLLFSSEKSSWRDCSEEEQKELLCHTLCDILESACCDHSGSYCLVSWLRGKTTEETASISGSPAESSCQVEHS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 chromosome 10 open reading frame 97
别名 C10orf97, CARP, Dermal papilla-derived protein 5, DERP5, Deubiquitinating enzyme MINDY-3
观测分子量49 kDa
GenBank蛋白编号BC067799
基因名称 C10orf97
Gene ID (NCBI) 80013
RRIDAB_3742191
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9H8M7
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MINDY3 (also known as FAM63B) is a deubiquitinating enzyme (DUB) localized to the endoplasmic reticulum and belongs to the MINDY family. This protein specifically recognizes and cleaves lysine 48 (K48)-linked ubiquitin chains, which serve as the primary signal targeting proteins for proteasomal degradation, thereby playing a critical role in regulating protein stability. Research indicates that MINDY3 influences various cellular processes through its deubiquitination activity, including endoplasmic reticulum-associated degradation (ERAD), cellular stress response, and cell cycle regulation. Dysregulation of its function is closely associated with pathological processes such as cancer and neurodegenerative diseases, making it a potential target for therapeutic research.

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