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验证数据展示

  • WB analysis using 33503-1-AP (same clone as 33503-1-PBS)

    WB analysis using 33503-1-AP (same clone as 33503-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33503-1-AP (MICALL1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33503-1-PBS in a different storage buffer formulation.

  • WB analysis of A549 using 33503-1-AP (same clone as 33503-1-PBS)

    WB analysis of A549 using 33503-1-AP (same clone as 33503-1-PBS)

    WB result of MICALL1 antibody (33503-1-AP; 1:1200; incubated at room temperature for 1.5 hours) with sh-Control and sh-MICALL1 transfected A549 cells. This data was developed using the same antibody clone with 33503-1-PBS in a different storage buffer formulation.

MICALL1 Polyclonal antibody, PBS Only

MICALL1 Polyclonal Antibody for WB, Indirect ELISA
Cat No. 33503-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Indirect ELISA

别名

KIAA1668, MICAL Like 1, MICAL-L1, MICAL-Like 1, MICAL-like protein 1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

33503-1-PBS targets MICALL1 in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag39169

Product name: Recombinant human MICALL1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 750-863 aa of NM_033386.3

Sequence: NLEQRQADVEYELRCLLNKPEKDWTEEDRAREKVLMQELVTLIEQRNAIINCLDEDRQREEEEDKMLEAMIKKKEFQREAEPEGKKKGKFKTMKMLKLLGNKRDAKSKSPRDKS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 MICAL-like 1
别名 KIAA1668, MICAL Like 1, MICAL-L1, MICAL-Like 1, MICAL-like protein 1
计算分子量93kDa，863aa
观测分子量125 kDa
GenBank蛋白编号NM_033386.3
基因名称 MICALL1
Gene ID (NCBI) 85377
RRIDAB_3742994
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDQ8N3F8
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MICALL1 (MICAL-like protein 1) is a protein involved in the regulation of cytoskeleton dynamics and is a member of the MICAL family. This protein interacts with other molecules through its N-terminal CH domain and C-terminal coiled-coil domain, primarily regulating the stability of microtubules and actin, thereby affecting processes such as cell shape, migration, and intracellular transport. Studies have shown that MICALL1 plays a key role in neuronal axon guidance, angiogenesis, and the establishment of epithelial cell polarity. Additionally, it binds to Rab GTPases (such as Rab8a) and is involved in vesicle transport and membrane remodeling. Aberrant expression of MICALL1 is associated with tumor metastasis and neurological diseases, with its molecular mechanisms involving precise regulation of cytoskeleton rearrangement, making it a potential therapeutic target.

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