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验证数据展示

  • WB analysis using 85933-1-RR (same clone as 85933-1-PBS)

    WB analysis using 85933-1-RR (same clone as 85933-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85933-1-RR (MGAT2 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85933-1-PBS in a different storage buffer formulation.

  • IF Staining of Raji using 85933-1-RR (same clone as 85933-1-PBS)

    IF Staining of Raji using 85933-1-RR (same clone as 85933-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed Raji cells using MGAT2 antibody (85933-1-RR, Clone: 250147B1 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 85933-1-PBS in a different storage buffer formulation.

MGAT2 Recombinant monoclonal antibody, PBS Only

MGAT2 Uni-rAb® Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 85933-1-PBS

产品说明书

CloneNo. 250147B1

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, Beta-1,2-N-acetylglucosaminyltransferase II, CDGS2, EC:2.4.1.143, GlcNAc T II

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy® MGAT2 Ready-To-Use IHC Kit. MGAT2 primary antibody included.

产品信息

85933-1-PBS targets MGAT2 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag8423

Product name: Recombinant human MGAT2 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 101-447 aa of BC006390

Sequence: DQTLRNVDKAGTWAPRELVLVVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVFFPFSIQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHFVWERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRSFYGMADKVDVKTWKSTEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPKFWKVLVPQIPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYMFPETLTISEKFTVVAISPPRKNGGWGDIRDHELCKSYRRLQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
别名 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, Beta-1,2-N-acetylglucosaminyltransferase II, CDGS2, EC:2.4.1.143, GlcNAc T II
计算分子量 447 aa, 52 kDa
观测分子量55-60 kDa
GenBank蛋白编号BC006390
基因名称 MGAT2
Gene ID (NCBI) 4247
RRIDAB_3744484
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ10469
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MGAT2 (Monoacylglycerol O-Acyltransferase 2) is a key enzyme in dietary fat absorption, catalyzing the rate-limiting step of monoacylglycerol (MAG) pathway for triacylglycerol (TAG) resynthesis in intestinal enterocytes. It plays a critical role in postprandial lipid metabolism by facilitating the re-esterification of absorbed fatty acids and monoacylglycerols into chylomicron-TAG for lymphatic transport. MGAT2 deficiency or pharmacological inhibition reduces fat absorption, lowers postprandial triglyceridemia, and protects against diet-induced obesity, hepatic steatosis, and insulin resistance in preclinical models. MGAT2 has emerged as a promising therapeutic target for metabolic diseases including obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD).

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