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验证数据展示

  • WB analysis using 17001-1-AP (same clone as 17001-1-PBS)

    WB analysis using 17001-1-AP (same clone as 17001-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 17001-1-AP (METTL7B antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17001-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse liver using 17001-1-AP (same clone as 17001-1-PBS)

    IHC staining of mouse liver using 17001-1-AP (same clone as 17001-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 17001-1-AP (METTL7B antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17001-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with METTL7B antibody included
  • IHC staining of mouse liver using 17001-1-AP (same clone as 17001-1-PBS)

    IHC staining of mouse liver using 17001-1-AP (same clone as 17001-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 17001-1-AP (METTL7B antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17001-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with METTL7B antibody included

METTL7B Polyclonal antibody, PBS Only

METTL7B Polyclonal Antibody for WB, IHC, ELISA
Cat No. 17001-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, ELISA

别名

EC:2.1.1.9, methyltransferase like 7B, Methyltransferase-like protein 7B, Thiol S-methyltransferase METTL7B, Thiol S-methyltransferase TMT1B

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy® METTL7B Ready-To-Use IHC Kit. METTL7B primary antibody included.

产品信息

17001-1-PBS targets METTL7B in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag10694

Product name: Recombinant human METTL7B protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 39-244 aa of BC020509

Sequence: MAVLTPKSNRKMESKKRELFSQIKGLTGASGKVALLELGCGTGANFQFYPPGCRVTCLDPNPHFEKFLTKSMAENRHLQYERFVVAPGEDMRQLADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPYGSWAFMWQQVFEPTWKHIGDGCCLTRETWKDLENAQFSEIQMERQPPPLKWLPVGPHIMGKAVK

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 methyltransferase like 7B
别名 EC:2.1.1.9, methyltransferase like 7B, Methyltransferase-like protein 7B, Thiol S-methyltransferase METTL7B, Thiol S-methyltransferase TMT1B
计算分子量244aa,28 kDa
观测分子量 28 kDa
GenBank蛋白编号BC020509
基因名称 METTL7B
Gene ID (NCBI) 196410
RRIDAB_2142199
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ6UX53
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

METTL7B is a membrane-associated small-molecule methyltransferase that catalyzes S-methylation of alkyl thiols, thereby linking thiol/sulfur metabolism, redox homeostasis, and cellular stress responses. By influencing antioxidant enzyme expression and detoxification pathways, METTL7B plays a pivotal role in tumor growth and drug resistance, particularly in lung adenocarcinoma. Its upregulation in multiple cancers and involvement in redox/thiol metabolism make it an emerging therapeutic target in oncology and possibly in metabolic/oxidative stress-related disease settings. (PMID: 40068772)

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