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验证数据展示

  • WB analysis of mouse liver using 21072-1-AP (same clone as 21072-1-PBS)

    WB analysis of mouse liver using 21072-1-AP (same clone as 21072-1-PBS)

    mouse liver tissue were subjected to SDS PAGE followed by western blot with 21072-1-AP (MEKK3 antibody at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21072-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse liver using 21072-1-AP (same clone as 21072-1-PBS)

    IP experiment of mouse liver using 21072-1-AP (same clone as 21072-1-PBS)

    IP result of anti-MEKK3 (IP:21072-1-AP, 4ug; Detection:21072-1-AP 1:300) with mouse liver tissue lysate 7000ug. This data was developed using the same antibody clone with 21072-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 21072-1-AP (same clone as 21072-1-PBS)

    IHC staining of human liver cancer using 21072-1-AP (same clone as 21072-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 21072-1-AP (MEKK3 antibody at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21072-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 21072-1-AP (same clone as 21072-1-PBS)

    IHC staining of human liver cancer using 21072-1-AP (same clone as 21072-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 21072-1-AP (MEKK3 antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21072-1-PBS in a different storage buffer formulation.

MEKK3 Polyclonal antibody, PBS Only

MEKK3 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 21072-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IP, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

21072-1-PBS targets MEKK3 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag15223

Product name: Recombinant human MAP3K3 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 281-366 aa of BC090859

Sequence: VSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPINWRRGK

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 mitogen-activated protein kinase kinase kinase 3
别名
计算分子量 657 aa, 74 kDa
观测分子量 71 kDa, 74 kDa
GenBank蛋白编号BC090859
基因名称 MEKK3
Gene ID (NCBI) 4215
RRIDAB_2878806
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ99759
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The mitogen-activated protein/ERK kinase kinase 3 (MEKK3) is a member of a family of MEKK/Ste11 serine/threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen-activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases. (PMID: 18206350).Cerebral cavernous malformations (CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2/4 may be targeted to develop new CCM therapeutics.

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