验证数据展示
产品信息
20081-1-AP targets MAS1-Specific in ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | MAS1 oncogene |
| 别名 | MAS, MAS1, MAS1 oncogene, Proto oncogene Mas |
| 计算分子量 | 37 kDa |
| GenBank蛋白编号 | NM_002377 |
| 基因名称 | MAS1 |
| Gene ID (NCBI) | 4142 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P04201 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
MAS1, also named as MAS, belongs to the G-protein coupled receptor 1 family. It is a receptor for angiotensin 1-7. MAS1 acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. MAS1 positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells. This antibody is specific to MAS1.