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验证数据展示

  • WB analysis of HeLa using 12213-1-AP (same clone as 12213-1-PBS)

    WB analysis of HeLa using 12213-1-AP (same clone as 12213-1-PBS)

    WB result of MARCH5 antibody (12213-1-AP; 1:300; incubated at room temperature for 1.5 hours) with sh-Control and sh-MARCH5 transfected HeLa cells. This data was developed using the same antibody clone with 12213-1-PBS in a different storage buffer formulation.

  • IHC staining of human skeletal muscle using 12213-1-AP (same clone as 12213-1-PBS)

    IHC staining of human skeletal muscle using 12213-1-AP (same clone as 12213-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human skeletal muscle tissue slide using 12213-1-AP (MARCH5 Antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 12213-1-PBS in a different storage buffer formulation.

  • IHC staining of human skeletal muscle using 12213-1-AP (same clone as 12213-1-PBS)

    IHC staining of human skeletal muscle using 12213-1-AP (same clone as 12213-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human skeletal muscle tissue slide using 12213-1-AP (MARCH5 Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 12213-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

MARCH5 Polyclonal antibody, PBS Only

MARCH5 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 12213-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

12213-1-PBS targets MARCH5 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag2806

Product name: Recombinant human MARCH5 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-209 aa of BC015480

Sequence: MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSIYWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRI

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 membrane-associated ring finger (C3HC4) 5
别名
计算分子量 278 aa, 31 kDa
观测分子量 31 kDa, 65-70 kDa
GenBank蛋白编号BC015480
基因名称 MARCH5
Gene ID (NCBI) 54708
RRIDAB_10638602
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9NX47
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MARCH5(E3 ubiquitin-protein ligase MARCH5) is a 31 kDa protein also named as RNF153. This protein plays a protective role against mitochondrial dysfunction caused by the mitochondrial accumulation of mSOD1 via the ubiquitin-proteasome pathway (PMID:19741096). And it may regulate MAP1B LC1 function in mitochondria by controlling mitochondrial aggregation via mitochondrial LC1 levels(PMID:22308378). MEARCH5 can exsit as a homodimer with MW 65-70 kDa.

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