MAPKAP1 Polyclonal antibody

MAPKAP1 Polyclonal Antibody for ELISA
Cat No. 20993-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

ELISA

JC310, MAPKAP1, MIP1, mSIN1, SAPK interacting protein 1, SIN1, SIN1b, SIN1g, TORC2 subunit MAPKAP1

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
规格: 

-/ -


产品信息

20993-1-AP targets MAPKAP1 in ELISA applications and shows reactivity with human samples.

经测试应用 ELISA Application Description
经测试反应性 human
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 mitogen-activated protein kinase associated protein 1
别名 JC310, MAPKAP1, MIP1, mSIN1, SAPK interacting protein 1, SIN1, SIN1b, SIN1g, TORC2 subunit MAPKAP1
计算分子量 59 kDa
GenBank蛋白编号NM_024117
基因名称 MAPKAP1
Gene ID (NCBI) 79109
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9BPZ7
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

MAPKAP1, also named as MIP1 and SIN1, belongs to the SIN1 family. It is a subunit of mTORC2 which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. It inhibits HRAS and KRAS signaling. MAPKAP1 enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. The antibody is specific to MAPKAP1. The antibody can recognize all the isoform of MAPKAP1.

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