The assembly of microtubules, an essential step in neurogenesis, is modulated by the family of microtubule-associated proteins (MAPs). These proteins have been divided into 2 main groups by molecular mass, high molecular weight MAPs, which include MAP1A, MAP1B, and MAP2, and another group of intermediate-sized proteins, which include the abundant tau MAPs. MAP1A is the largest brain MAP and is expressed prominently in dendrites and to a lesser extent in cell bodies and axons. This protein is involved in differentiation of axons and dendrites as well as maintenance of the microtubule cytoskeleton in mature neurons. This antibody recognizes MAP1 light chain LC2.