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验证数据展示

  • WB analysis of K-562 using 24202-1-AP (same clone as 24202-1-PBS)

    WB analysis of K-562 using 24202-1-AP (same clone as 24202-1-PBS)

    K-562 cells were subjected to SDS PAGE followed by western blot with 24202-1-AP (LUC7L2 Antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 24202-1-AP (same clone as 24202-1-PBS)

    WB analysis of HeLa using 24202-1-AP (same clone as 24202-1-PBS)

    WB result of LUC7L2 antibody (24202-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-LUC7L2 transfected HeLa cells. This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

  • IF Staining of A431 using 24202-1-AP (same clone as 24202-1-PBS)

    IF Staining of A431 using 24202-1-AP (same clone as 24202-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A431 cells using LUC7L2 antibody (24202-1-AP) at dilution of 1:600 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red). This data was developed using the same antibody clone with 24202-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

LUC7L2 Polyclonal antibody, PBS Only

LUC7L2 Polyclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 24202-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

24202-1-PBS targets LUC7L2 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag21135

Product name: Recombinant human LUC7L2 protein

Source: e coli.-derived, PET30a

Tag: 6*His

Domain: 1-392 aa of BC017163

Sequence: MSAQAQMRAMLDQLMGTSRDGDTTRQRIKFSDDRVCKSHLLNCCPHDVLSGTRMDLGECLKVHDLALRADYEIASKEQDFFFELDAMDHLQSFIADCDRRTEVAKKRLAETQEEISAEVAAKAERVHELNEEIGKLLAKVEQLGAEGNVEESQKVMDEVEKARAKKREAEEVYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIEIREKLEELKRVVAEKQEKRNQERLKRREEREREEREKLRRSRSHSKNPKRSRSREHRRHRSRSMSRERKRRTRSKSREKRHRHRSRSSSRSRSRSHQRSRHSSRDRSRERSKRRSSKERFRDQDLASCDRDRSSRDRSPRDRDRKDKKRSYESANGRSEDRRSSEEREAGEI

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 LUC7-like 2 (S. cerevisiae)
别名
计算分子量 392 aa, 47 kDa
观测分子量 46 kDa
GenBank蛋白编号BC017163
基因名称 LUC7L2
Gene ID (NCBI) 51631
RRIDAB_2879455
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen Affinity purified
UNIPROT IDQ9Y383
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

RNA-binding protein LUC7L2 as a negative regulator of DNA virus-triggered innate immune response. Mechanistically, LUC7L2 directly bound to intron 3 of MITA precursor messenger RNA, inhibited its splicing, and promoted its nonsense-mediated decay, leading to its downregulation at the protein level (PMID:34155193). Moreover, LUC7L2 as a component of the U1 snRNP capable of reprogramming cellular metabolism through changes in alternative pre-mRNA splicing (PMID:33961773).

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