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验证数据展示

  • WB analysis using 17155-1-AP (same clone as 17155-1-PBS)

    WB analysis using 17155-1-AP (same clone as 17155-1-PBS)

    Mouse brain tissue were subjected to SDS PAGE followed by western blot with 17155-1-AP (LRRC8A/SWELL1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17155-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse brain using 17155-1-AP (same clone as 17155-1-PBS)

    IP experiment of mouse brain using 17155-1-AP (same clone as 17155-1-PBS)

    IP result of anti-LRRC8A/SWELL1 (IP:17155-1-AP, 4ug; Detection:17155-1-AP 1:800) with mouse brain tissue lysate 2100 ug. This data was developed using the same antibody clone with 17155-1-PBS in a different storage buffer formulation.

LRRC8A/SWELL1 Polyclonal antibody, PBS Only

LRRC8A/SWELL1 Polyclonal Antibody for WB, IP, Indirect ELISA
Cat No. 17155-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IP, Indirect ELISA

别名

LRRC8A, HsLRRC8A, KIAA1437, Leucine-rich repeat-containing protein 8A, LRRC8

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

17155-1-PBS targets LRRC8A/SWELL1 in WB, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag10062

Product name: Recombinant human LRRC8A protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 464-810 aa of BC051322

Sequence: SIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEVKERLWRADKEQA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 leucine rich repeat containing 8 family, member A
别名 LRRC8A, HsLRRC8A, KIAA1437, Leucine-rich repeat-containing protein 8A, LRRC8
计算分子量 810 aa, 94 kDa
观测分子量94 kDa
GenBank蛋白编号BC051322
基因名称 LRRC8A
Gene ID (NCBI) 56262
RRIDAB_2918050
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8IWT6
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

LRRC8A, also named as SWELL1, KIAA1437, and LRRC8, belongs to the LRRC8 family. LRRC8A is the essential subunit of the volume-regulated anion channel (VRAC), a key regulator of cell volume homeostasis. It forms heteromeric channels with other LRRC8 family members (B-E) to transport chloride, organic osmolytes, and drugs. This channel is crucial for processes like regulatory volume decrease (RVD), cell proliferation, and migration. Dysfunction of LRRC8A-VRAC is implicated in cancer chemotherapy resistance, stroke, and immune disorders (PMID: 24790029, PMID: 39550567, PMID: 40642832). The molecular weight of LRRC8A is 94 kDa.

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