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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 84973-1-RR (same clone as 84973-1-PBS)

    WB analysis using 84973-1-RR (same clone as 84973-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84973-1-RR (LRP4 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84973-1-PBS in a different storage buffer formulation.

  • IF Staining of PC-12 using 84973-1-RR (same clone as 84973-1-PBS)

    IF Staining of PC-12 using 84973-1-RR (same clone as 84973-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed PC-12 cells using LRP4 antibody (84973-1-RR, Clone: 242157D11 ) at dilution of 1:500 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84973-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84973-1-RR

    Affinity and Kinetic Characterization of 84973-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84973-1-RR against Human LRP4 were performed. The affinity constant is 70.0 nM.

LRP4 Recombinant antibody, PBS Only

LRP4 Uni-rAbTM Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 84973-1-PBS

产品说明书

CloneNo. 242157D11

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IF/ICC, Indirect ELISA

别名

242157D11, KIAA0816, Low-density lipoprotein receptor-related protein 4, LRP 4, LRP10

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

84973-1-PBS targets LRP4 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 LRP4 fusion protein Ag19413 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 low density lipoprotein receptor-related protein 4
别名 242157D11, KIAA0816, Low-density lipoprotein receptor-related protein 4, LRP 4, LRP10
计算分子量 1905 aa, 212 kDa
观测分子量245 kDa
GenBank蛋白编号BC136667
基因名称 LRP4
Gene ID (NCBI) 4038
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDO75096
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

LRP4 (low-density lipoprotein receptor-related protein 4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a type I single transmembrane protein of the low-density lipoprotein receptor (LDLR) family. LRP4 is composed of a large extracellular region containing multiple LDLa repeats, EGF-like domains and β-propeller domains, a transmembrane region and a cytoplasmic region containing an NPxY motif and a PDZ-interacting motif (PMID: 26071838). LRP4 binds agrin and recruits it to the MuSK signaling complex, which is critical for neuromuscular junction formation (PMID: 17119023; 18957220). LPR4 mutation or malfunction is implicated in disorders including congenital myasthenic syndrome, myasthenia gravis, and diseases of bone or kidney (26071838).