• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • IHC staining of mouse spleen using 83941-7-RR (same clone as 83941-7-PBS)

    IHC staining of mouse spleen using 83941-7-RR (same clone as 83941-7-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 83941-7-RR (LAG-3/CD223 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83941-7-PBS in a different storage buffer formulation.

  • IHC staining of mouse spleen using 83941-7-RR (same clone as 83941-7-PBS)

    IHC staining of mouse spleen using 83941-7-RR (same clone as 83941-7-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse spleen tissue slide using 83941-7-RR (LAG-3/CD223 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83941-7-PBS in a different storage buffer formulation.

Mouse LAG-3/CD223 Recombinant antibody, PBS Only

LAG-3/CD223 Uni-rAbTM Recombinant Antibody for IHC, Indirect ELISA
Cat No. 83941-7-PBS

产品说明书

CloneNo. 241007B1

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

IHC, Indirect ELISA

别名

CD223, LAG-3, LAG 3, Lag3, Ly66

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

点击咨询售前客服

点击咨询售后客服

产品信息

83941-7-PBS targets LAG-3/CD223 in IHC, Indirect ELISA applications and shows reactivity with mouse samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 mouse
免疫原 LAG-3/CD223 fusion protein Eg1220 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 lymphocyte-activation gene 3
别名 CD223, LAG-3, LAG 3, Lag3, Ly66
计算分子量57kDa
GenBank蛋白编号NM_008479.2
基因名称 CD223
Gene ID (NCBI) 16768
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ61790
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

LAG-3, also known as CD223, is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. LAG-3 is expressed on activated T cells, NK cells, regulatory T cells, and plasmacytoid dendritic cells. It is a CD4-related molecule that binds MHC class II. LAG-3 plays an important role in modulating T cell expansion and function, and blockade of LAG-3 with monoclonal antibodies can augment T cell function. (PMID: 15634887; 21086108; 28783703)