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验证数据展示

  • WB analysis using 86299-3-RR (same clone as 86299-3-PBS)

    WB analysis using 86299-3-RR (same clone as 86299-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86299-3-RR (L-Plastin antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86299-3-PBS in a different storage buffer formulation.

  • IF Staining of Jurkat using 86299-3-RR (same clone as 86299-3-PBS)

    IF Staining of Jurkat using 86299-3-RR (same clone as 86299-3-PBS)

    Immunofluorescent analysis of (4% PFA) fixed Jurkat cells using L-Plastin antibody (86299-3-RR, Clone: 251063A3 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 86299-3-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86299-3-RR

    Affinity and Kinetic Characterization of 86299-3-RR

    Biolayer interferometry (BLl) kinetic assays of 86299-3-RR against Human L-Plastin were performed. The affinity constant is 5.27 nM.

L-Plastin Recombinant monoclonal antibody, PBS Only

L-Plastin Uni-rAb® Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 86299-3-PBS

产品说明书

CloneNo. 251063A3

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IF/ICC, Indirect ELISA

别名

LCP1, L PLASTIN, LCP 1, LCP-1, LPL

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

86299-3-PBS targets L-Plastin in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag3571

Product name: Recombinant human LCP1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 278-627 aa of BC010271

Sequence: LENAGCNKIGNFSTDIKDSKAYYHLLEQVAPKGDEEGVPAVVIDMSGLREKDDIQRAECMLQQAERLGCRQFVTATDVVRGNPKLNLAFIANLFNRYPALHKPENQDIDWGALEGETREERTFRNWMNSLGVNPRVNHLYSDLSDALVIFQLYEKIKVPVDWNRVNKPPYPKLGGNMKKLENCNYAVELGKNQAKFSLVGIGGQDLNEGNRTLTLALIWQLMRRYTLNILEEIGGGQKVNDDIIVNWVNETLREAEKSSSISSFKDPKISTSLPVLDLIDAIQPGSINYDLLKTENLNDDEKLNNAKYAISMARKIGARVYALPEDLVEVNPKMVMTVFACLMGKGMKRV

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 lymphocyte cytosolic protein 1 (L-plastin)
别名 LCP1, L PLASTIN, LCP 1, LCP-1, LPL
计算分子量 627 aa, 64 kDa
观测分子量 64-70 kDa
GenBank蛋白编号BC010271
基因名称 L-Plastin
Gene ID (NCBI) 3936
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP13796
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

LCP1, also known as L-Plastin, is a member of the Plastin gene family. The family members include L-Plastin (LCP1), T-Plastin (PLS3), and I-Plastin (PLS1), which can regulate the dynamic reorganization of the cytoskeleton by binding and cross-linking actin filaments. In lymphocytes, LCP1 can regulate immune responses, especially during inflammation and infection. It acts as a key regulator of T-cell activation by responding to co-stimulatory signals through TCR/CD3 and CD2 or CD28, and regulates the cell-surface expression of IL2RA/CD25 and CD69 (PMID: 17294403).

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