验证数据展示
产品信息
85168-1-PBS targets KIR2DL1 in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Recombinant protein 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 |
| 别名 | 242070D11, CD158 antigen-like family member A, CD158a, Killer cell immunoglobulin-like receptor 2DL1, Natural killer-associated transcript 1 |
| 计算分子量 | 39 kDa |
| 观测分子量 | 45 kDa |
| GenBank蛋白编号 | BC069344 |
| 基因名称 | KIR2DL1 |
| Gene ID (NCBI) | 3802 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purfication |
| UNIPROT ID | P43626 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1, also known as CD158A and NKAT1) is an inhibitory receptor of NK cells, with β-arrestin 2 mediated recruitment of the tyrosine phosphatases SHP-1 and SHP-2 to KIR2DL1 and facilitated downstream inhibitory signaling (PMID: 18604210). The effector function of NK cells expressing KIR2DL1 or KIR2DS1 is highly influenced by genetic variability and is calibrated by co-expression of additional NK receptors and cognate HLA-C2 ligands (PMID: 31024561).
