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验证数据展示

  • IF Staining of HeLa using 14426-1-AP (same clone as 14426-1-PBS)

    IF Staining of HeLa using 14426-1-AP (same clone as 14426-1-PBS)

    Immunofluorescent analysis of (10% Formaldehyde) fixed HeLa cells using 14426-1-AP (KDM5C antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 14426-1-PBS in a different storage buffer formulation.

  • WB analysis using 14426-1-AP (same clone as 14426-1-PBS)

    WB analysis using 14426-1-AP (same clone as 14426-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 14426-1-AP (KDM5C antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14426-1-PBS in a different storage buffer formulation.

KDM5C Polyclonal antibody, PBS Only

KDM5C Polyclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 14426-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IF/ICC, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

14426-1-PBS targets KDM5C in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag5791

Product name: Recombinant human KDM5C protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-351 aa of BC054499

Sequence: MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIF

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 lysine (K)-specific demethylase 5C
别名
计算分子量 176 kDa
观测分子量 171-180 kDa
GenBank蛋白编号BC054499
基因名称 KDM5C
Gene ID (NCBI) 8242
RRIDAB_10837073
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP41229
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

KDM5C belongs to the ARID protein family that harbors conserved DNA-binding motifs and acts as a histone H3 lysine 4 demethylase, suggesting a potential role in epigenetic regulation during development, cell differentiation (PMID:21575681). KDM5C protein is homologous to three other proteins of the human JARID1 family (JARID1A, JARID1B and JARID1C). This family shares several evolutionarily conserved domains, including the catalytic JmjC domain, JmjN domain, Arid/Bright domain, C5HC2 zinc-finger domain and two plant homeodomains (PHD), a motif that binds methyl-lysine residues (PMID:17320160,17320161).

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