验证数据展示
产品信息
20038-1-AP targets KDM4B in ELISA applications and shows reactivity with human samples.
经测试应用 | ELISA Application Description |
经测试反应性 | human |
免疫原 | Peptide 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | lysine (K)-specific demethylase 4B |
别名 | JHDM3B, JMJD2B, KDM4B, KIAA0876, lysine (K) demethylase 4B, Lysine specific demethylase 4B |
计算分子量 | 122 kDa |
GenBank蛋白编号 | NM_015015 |
基因名称 | KDM4B |
Gene ID (NCBI) | 23030 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | O94953 |
储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
KDM4B, also named as JHDM3B, JMJD2B and KIAA0876, belongs to the JHDM3 histone demethylase family. KDM4B is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. It does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. KDM4B is able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. The antibody recognizes near the C-term of KDM4B and has no cross reaction to KDM4A.